In which part of the body do medications dissolve before absorption?

Medications dissolve in the gastrointestinal (GI) contents before they are absorbed into the bloodstream. This is primarily due to the fact that most medications are administered orally, and once ingested, they enter the stomach and intestines, where the acidic and enzymatic environment aids in the dissolution process. Once the medications are in solution, they can be absorbed through the intestinal lining into the bloodstream. This process is essential for the medications to be effective, as they must first dissolve to allow the active ingredients to enter the systemic circulation and reach their target sites within the body.

The bloodstream is involved in the distribution of the medications after absorption, while muscle tissue and the liver play roles in drug metabolism and distribution, but they are not the primary sites for the dissolution of medications prior to absorption.